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91.
层状富锂材料具有超过250 mAh∙g−1的高可逆比容量,被认为是下一代高比能锂离子电池最具商业化前景的正极材料之一。然而,层状富锂材料在实际应用之前仍需解决诸多挑战,如高电压氧释放、层状到岩盐相的结构变化、过渡金属离子迁移等结构劣化,并由此带来了较低的初始库伦效率、电压/容量的衰减以及循环寿命的不足。针对以上问题,进行层状富锂材料改性无疑是一种行之有效的方法。本综述全面介绍了层状富锂材料的结构、组分以及电化学性能,在此基础上对材料改性策略进行了系统阐述,详细介绍了体相掺杂、表面包覆、缺陷设计、离子交换和微结构调控等一系列改性策略的现状以及发展趋势,最终提出了高容量和长循环层状富锂材料和高比能锂离子电池的设计思路。 相似文献
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结合大学化学的教学现状,针对学生的需求,深入思考在教学过程中设置习题课的重要性和相关问题。从教师素质、班级规模、教学方法、习题构建与讲解以及考试等不同角度提出有效提高习题课效率的策略。进一步探讨线上线下混合式习题课教学模式的可行性,并提供可参考的教学案例,以期促进大学化学专业课程的教与学。 相似文献
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Parvateesam Yenda Naresh Kumar Katari Balasubramanian Satheesh Rambabu Gundla Siva Krishna Muchakayala Vijay Kumar Rekulapally 《Journal of separation science》2023,46(11):2200770
The design of an appropriate analytical method for assessing the quality of pharmaceuticals requires a deep understanding of science, and risk evaluation approaches are appreciated. The current study discusses how a related substance method was developed for Nintedanib esylate. The best possible separation between the critical peak pairs was achieved using an X-Select charged surface hybrid Phenyl Hexyl (150 × 4.6) mm, 3.5 μm column. A mixture of water, acetonitrile, and methanol in mobile phase-A (70:20:10) and mobile phase-B (20:70:10), with 0.1% trifluoroacetic acid and 0.05% formic acid in both eluents. The set flow rate, wavelength, and injection volumes were 1.0 ml/min, 285 nm, and 5 μl, respectively, with gradient elution. The method conditions were validated as per regulatory requirements and United States Pharmacopeia general chapter < 1225 >. The correlation coefficient for all impurities from the linearity experiment was found to be > 0.999. The % relative standard deviation from the precision experiments ranged from 0.4 to 3.6. The mean %recovery from the accuracy study ranged from 92.5 to 106.5. Demonstrated the power of the stability-indicating method through degradation studies; the active drug component is more vulnerable to oxidation than other conditions. Final method conditions were further evaluated using a full-factorial design. The robust method conditions were identified using the graphical optimization from the design space. 相似文献
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《Arabian Journal of Chemistry》2023,16(2):104499
In medicinal chemistry for the purpose of lead optimization, hit selection of new isofunctional chemotypes are crucial for the success of identifying novel chemical entities of increased potency. Using fragment-based design approach with the N-selective inhibitor RXP407, a novel phosphinic peptide scaffold that consisted of modified RXP407 fragments was generated. The presented synthetic route is straightforward and produces the desired product Z-RXP407 in moderate yield. The (S,R,S,S)-Z-RXP407 analog has been evaluated for the C- and N-domain constructs of angiotensin-converting enzyme. The potency of this analog has been much lower compared to the parent compound RXP407, providing thus valuable insights regarding further design based on structure–activity relationships. 相似文献
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Miguel Reina Eduardo Gabriel Guzmán-López Annia Galano 《International journal of quantum chemistry》2023,123(2):e27011
A set of new rasagiline derivatives is presented. They were designed to be antioxidant compounds with the potential to be used for treating neurodegenerative disorders. They are expected to be multifunctional molecules that can help reduce oxidative stress, which is thought to contribute to neurodegenerative disorders. The CADMA-Chem computational protocol was used to produce rasagiline derivatives and to evaluate their likeliness as oral drugs and antioxidants. Three of them were identified as the most promising ones. They are proposed to be better free radical scavengers than rasagiline. In addition, they are expected to keep the parent's molecule neuroprotective capability. Hopefully, the results presented here would promote further experimental and theoretical investigations on these compounds. 相似文献
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基于逆向教学设计的特点及实践,分析了传统逆向教学设计的课堂实现中存在的关于预期评估与实际评估脱节的问题,阐述了教学反馈的重要性。从而提出了一种重视反馈的逆向教学设计方法。这种方法将评估预判和反馈策略充分结合到逆向教学设计中,在评估和反馈之间进行了有效关联,很好地解决了以上问题。结合笔者在质谱课程中的实践经验,对相应的教学设计的过程进行了举例说明。 相似文献
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